Karateka (Apple II)

Karateka is a rotoscoped side-scrolling brawler in which a stiff-legged karate man kicks everything. Even birds.

Upside-Down
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While Karateka only takes up Side A, Side B contains a copy of the game modified to play upside-down. According to Jordan Mechner, this was a practical joke by Brøderbund so tech support could have the delight of telling someone that their game was upside-down because...they put the disc in upside-down. Duh.